Bristol Myers Squibb Hiring for Senior Scientist, Mass Spectrometry at Cambridge, Massachusetts Full Time

At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

The Leads Discovery & Optimization (LDO) is a dynamic organization that supports the entire continuum of drug discovery (from lead identification to clinical candidate delivery) at Bristol Myers Squibb. The organization leverages state of the art technologies, complemented by deep subject matter expertise and broad scientific knowledge, to deliver innovative and comprehensive preclinical in vitro datasets to support our drug discovery pipeline in disease areas such as cell therapy, oncology, immunology, fibrosis and cardiovascular diseases.

The Biochemistry & Biophysics Team in Lead Discovery & Optimization at Bristol Myers Squibb in Cambridge is seeking a highly motivated mass spectrometry specialist for a Scientist position. The successful candidate will apply mass spectrometry to characterize recombinant proteins, study protein modifications and degradations, and develop analytical methods for small molecule detection to characterize biochemical reactions and interrogate small molecule inhibition of enzymes. An ideal candidate would also have some experience in biophysical characterization of protein and protein-small molecule interactions via mass spectrometry using techniques such as HDX-MS

Responsibilities:

• Develop, optimize, validate, trouble shoot, and execute protein characterization, modification, and degradation experiments using mass spectrometry

• Develop, optimize, validate, trouble shoot, and execute biochemical and biophysical assays on the interaction of recombinant proteins with small molecule inhibitors/binders using mass spectrometry

• Maintain mass spectrometry equipment to ensure good working order

• Perform plate-based biochemical and biophysical assays as needed

• Analyze and report assay results to the corporate database and project teams

Technical Skills:

• Ph.D. degree, a M.S. degree with at least 2 years of experience

• Solid training and hands-on experience with quantitative LC-MS and LC-MS/MS analysis of recombinant proteins and protein modifications and degradations in cell-free environment and cell cultures

• Solid training and hands-on experience with quantitative LC-MS and LC-MS/MS analysis of small molecule transformation in enzymatic reactions and protein-small molecule interaction matrices

• Experience and understanding of separation techniques to isolate molecules of interest

• Training with software needed for data analysis and interpretation

• Experience with plate-based biochemical and biophysical assays and analysis of enzyme inhibition data and binding isotherms is a strong plus

• Familiarity with MALDI MS and/or high throughput screening is a plus

Other Attributes:

• Function independently within project teams

• Reliably execute on team responsibilities in a timely manner

• Strong communication and organization skills

• Highly self-motivated & fueled by a fundamental interest in contributing to science in general, and drug discovery in particular

• Ability to influence in a matrix environment

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to [email protected] . Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Company: Bristol Myers Squibb

Req Number: R1548411

Updated: 2021-10-19 03:27:26.552 UTC

Location: Cambridge,Massachusetts

Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.